The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41423-023-01091-0.pdf
Reference77 articles.
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2. Schulert GS, Grom AA. Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies. Annu Rev Med. 2015;66:145–59.
3. Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76:16–32.
4. Emgard J, Bergsten H, McCormick JK, Barrantes I, Skrede S, Sandberg JK, et al. MAIT cells are major contributors to the cytokine response in group a streptococcal toxic shock syndrome. Proc Natl Acad Sci USA. 2019;116:25923–31.
5. Kopf M, Bachmann MF, Marsland BJ. Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov. 2010;9:703–18.
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1. Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage;Cellular & Molecular Immunology;2023-12-18
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