Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/23962.pdf
Reference30 articles.
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3. Alcorta, D. A.et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl Acad. Sci. USA 93, 13742–13747 (1996).
4. Allsopp, R. C.et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA 89, 10114–10118 (1992).
5. Bodnar, A. G.et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998).
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