1. 1. Plaut, M. & Lichtenstein, L. M. in Pharmacology of Histamine Receptors (eds Ganellin, C. R. & Parsons, M. E.) 392–435 (Wright PSG, Bristol 1982). 2. Hakanson, R. & Owman, C. Life Sci. 6, 759–766 (1967). 3. Schwartz, J.-C., Garbarg, M. & Pollard, H. in Handbook of Physiology, the Nervous System, Vol. IV: Intrinsic Regulatory Systems of the Brain (eds Bloom, F. E., Mountcastle, W. B. & Geiger, S. R.) 257–316 (American Physiological Society, Bethesda, 1986). 4. Happola, O., Soinila, S., Paivarinta, H., Panula, P. & Eranko- d. Histochemistry 82, 1–3 (1985). 5. Berridge, M. J. & Irvine, R. F. Nature 312, 315–321 (1984). 6. Hegstrand, L. R., Kanof, P. D. & Greengard, P. Nature 260, 163–165 (1976). 7. Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R. & Parsons, M. E. Nature 236,385–390(1972). 8. Arrang, J.-M., Garbarg, M. & Schwartz, J.-C. Nature 302, 832–837 (1983). 9. Arrang, J.-M., Garbarg, M. & Schwartz, J.-C. Neuroscience 15, 553–562 (1985). 10. Arrang, J.-M., Garbarg, M. & Schwartz, J.-C. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.–C.) 143–153 (Pergamon, Oxford, 1985). 11. Ganellin, C. R. in Pharmacology of Histamine Receptors (ed Ganellin, C. R. & Parsons, M. E.) 10–102 (Wright PSG, Bristol, 1982). 12. Schunack, W., Schwarz, S., Gerhard, G., Buyiiktimkin, S. & Elz, S. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.-C) 39–46 (Pergamon, Oxford, 1985). 13. Arrang, J.-M., Schwartz, J.-C. & Schunack, W. Eur. J. Pharmac. 117, 109–114 (1985). 14. Schwartz, J.-C., Arrang, J.-M., Garbarg, M. & Korner, M. J. exp. Biol. 124, 203–224 (1986). 15. Arrang, J.-M. et al. Eur. J. Pharmac. Ill, 73–84 (1985). 16. Gaddum, J. H. / PhysioL, Lond. 89. 7P–9P (1937). 17. Cheng, Y. C. & Prusoff, W. H. Biochem. Pharmac. 22, 3099–3108 (1973). 18. Baudry, M., Martres, M. P. & Schwartz, J.-C. Brain Res. 116, 111–124 (1976). 19. U'Prichard, D. C., Greenberg, D. A. & Snyder, S. H. Molec. Pharmac. 13, 454–473 (1977). 20. Yamamura, H. I. & Snyder, S. H. Molec. Pharmac. 10, 861–867 (1974). 21. Pert, C. B. & Snyder, S. H. Science 179, 1011–1014 (1973). 22. Martres, M. P., Bouthenet, M. L., Sales, N., Sokoloff, P. & Schwartz, J.-C. Science 228, 752–755 (1985). 23. Peroutka, S. J. & Snyder, S. H. Molec. Pharmac. 16, 687–699 (1979). 24. Leysen, J. E., Niemegeers, C. J. E., Tollenaere, J. P. & Laduron, P. M. Nature 272,168–171 (1978). 25. Schwartz, J.-C., Arrang, J.-M., Garbarg, M. & Schunack, W. in Innovative Approaches in Drug Research (ed. Harms, A. F.) 73–89 (Elsevier, Amsterdam, 1986). 26. Garbarg, M., Barbin, G., Rodergas, E. & Schwartz, J.-C. /. Neurochem. 35,1045–1052 (1980). 27. Watanabe, T. et al. Neurosci. Lett. 39, 249–254 (1983). 28. Steinbusch, H. W. M. & Mulder, A. H. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.-C.) 119–130 (Pergamon, Oxford, 1985). 29. Eyre, P. & Chand, N. in Pharmacology of Histamine Receptors (eds Ganellin, C. R. & Parsons, M. E.) 298–322 (Wright PSG, Bristol, 1982). 30. Pearce, F. L. et al. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.-C.) 411–422 (Pergamon, Oxford, 1985). 31. Hill, S. J., Emson, P. C. & Young, J. M. /. Neurochem. 31, 997–1004 (1978). 32. Tran, V. T., Chang, R. S. L. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 75,6290–6294 (1978). 33. Gajtkowski, G. A., Norris, D. B., Rising, T. J. & Wood, T. P. Nature 304, 65–67 (1983). 34. Langer, S. Z. Br. J. Pharmac. 60, 481–497 (1977). 35. Starke, K. A. Rev. Pharmac. Tox. 21, 7–30 (1981). 36. Stjarne, L. in Chemical Neurotransmission 75 Years. Karolinska Institutet, Nobel Conference No. 2 (eds Stjarne, L., Hedqvist, P., Lagercrantz, H. & Wennmalm, A.) 257–272 (Academic, London, 1981). 37. Schoffelmeer, A. N. M., Wierenga, E. A. & Mulder, A. H. / Neurochem. 46, 1711–1717 (1986). 38. Schwartz, J.-C. A. Rev. Pharmac. Tox. 17, 325–339 (1977). 39. Vanni-Mercier, G., Sakai, K. & Jouvet, M. C.r. hebd. Seanc. Acad. Sci., Paris 298, 195–200 (1984). 40. Lin, J.-S., Sakai, K. & Jouvet, M. C.R. hebd. Seanc. Acad. Sci., Paris 303, 469–474 (1986). 41. Gross, P. M. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.-C.) 341–352 (Pergamon, Oxford, 1985). 42. Quach, T. T., Duchemin, A. M., Rose, C. & Schwartz, J.-C. Molec. Pharmac. 17, 301–308 (1980). 43. Tuomisto, J. & Mannisto, P. Pharmac. Rev. 37, 249–332 (1985). 44. Gerhard, G. & Schunack, W. Arch. Pharm., Weinheim 313, 709–714 (1980). 45. Schunack, W. Arzneimittel-Forsch. 28, 2199–2202 (1978). 46. Kollonitsch, J. et al. Nature 274, 906–908 (1978). 47. Garbarg, M., Pollard, H., Quach, T. T. & Schwartz, J.-C. in Methods in Biogenic Amines Research (eds Parvez, S., Nagatsu, T., Nagatsu, I. & Parvez, H.) 623–662 (Elsevier, Amsterdam, 1983). 48. Saeki, K., Oishi, R. & Nishibori, M. in Frontiers in Histamine Research (eds Ganellin, C. R. & Schwartz, J.-C.) 173–184 (Pergamon, Oxford, 1985). 49. Parker, R. B. & Waud, D. R. J. Pharmac. exp. Therap. 177, 1–12 (1971). 50. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, London, 1982).