Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/leu2015271.pdf
Reference15 articles.
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2. Sangkhae V, Etheridge SL, Kaushansky K, Hitchcock IS . The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. Blood 2014; 124: 3956–3963.
3. Staerk J, Lacout C, Sato T, Smith SO, Vainchenker W, Constantinescu SN . An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood 2006; 107: 1864–1871.
4. Defour JP, Itaya M, Gryshkova V, Brett IC, Pecquet C, Sato T et al. Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation. Proc Natl Acad Sci USA 2013; 110: 2540–2545.
5. Abe M, Suzuki K, Inagaki O, Sassa S, Shikama H . A novel MPL point mutation resulting in thrombopoietin-independent activation. Leukemia 2002; 16: 1500–1506.
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