Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
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Published:2024-01-16
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ISSN:1359-4184
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Container-title:Molecular Psychiatry
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language:en
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Short-container-title:Mol Psychiatry
Author:
Vriend ChrisORCID, de Joode Niels T.ORCID, Pouwels Petra J. W.ORCID, Liu Feng, Otaduy Maria C. G.ORCID, Pastorello Bruno, Robertson Frances C., Ipser Jonathan, Lee Seonjoo, Hezel Dianne M., van Meter Page E., Batistuzzo Marcelo C.ORCID, Hoexter Marcelo Q., Sheshachala Karthik, Narayanaswamy Janardhanan C., Venkatasubramanian GanesanORCID, Lochner ChristineORCID, Miguel Euripedes C.ORCID, Reddy Y. C. Janardhan, Shavitt Roseli G., Stein Dan J.ORCID, Wall Melanie, Simpson Helen Blair, van den Heuvel Odile A.ORCID
Abstract
AbstractPrevious diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation in demographic and clinical characteristics, scanning methods, and underpowered samples. The OCD global study was created across five international sites to overcome these challenges by harmonizing data collection to identify consistent brain signatures of OCD that are reproducible and generalizable. Single-shell diffusion measures (e.g., fractional anisotropy), multi-shell Neurite Orientation Dispersion and Density Imaging (NODDI) and fixel-based measures, were extracted from skeletonized white matter tracts in 260 medication-free adults with OCD and 252 healthy controls. We additionally performed structural connectome analysis. We compared cases with controls and cases with early (<18) versus late (18+) OCD onset using mixed-model and Bayesian multilevel analysis. Compared with healthy controls, adult OCD individuals showed higher fiber density in the sagittal stratum (B[SE] = 0.10[0.05], P = 0.04) and credible evidence for higher fiber density in several other tracts. When comparing early (n = 145) and late-onset (n = 114) cases, converging evidence showed lower integrity of the posterior thalamic radiation —particularly radial diffusivity (B[SE] = 0.28[0.12], P = 0.03)—and lower global efficiency of the structural connectome (B[SE] = 15.3[6.6], P = 0.03) in late-onset cases. Post-hoc analyses indicated divergent direction of effects of the two OCD groups compared to healthy controls. Age of OCD onset differentially affects the integrity of thalamo-parietal/occipital tracts and the efficiency of the structural brain network. These results lend further support for the role of the thalamus and its afferent fibers and visual attentional processes in the pathophysiology of OCD.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology
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