27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen-Reference-Cited by-同舟云学术

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Published:2007-09-16 Issue:10 Volume:13 Page:1185-1192
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Umetani Michihisa,Domoto Hideharu,Gormley Andrew K,Yuhanna Ivan S,Cummins Carolyn L,Javitt Norman B,Korach Kenneth S,Shaul Philip W,Mangelsdorf David J

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1641.pdf

Reference49 articles.

1. Deroo, B.J. & Korach, K.S. Estrogen receptors and human disease. J. Clin. Invest. 116, 561–570 (2006).

2. Mendelsohn, M.E. & Karas, R.H. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 340, 1801–1811 (1999).

3. Lindner, V. et al. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ. Res. 83, 224–229 (1998).

4. Brouchet, L. et al. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 103, 423–428 (2001).

5. Pare, G. et al. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ. Res. 90, 1087–1092 (2002).

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