The evolving role of investigative toxicology in the pharmaceutical industry

Author:

Pognan FrancoisORCID,Beilmann Mario,Boonen Harrie C. M.,Czich Andreas,Dear Gordon,Hewitt Philip,Mow Tomas,Oinonen Teija,Roth Adrian,Steger-Hartmann Thomas,Valentin Jean-PierreORCID,Van Goethem Freddy,Weaver Richard J.ORCID,Newham PeterORCID

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference224 articles.

1. Weaver, R. J. & Valentin, J. P. Today’s challenges to de-risk and predict drug safety in human “Mind-the-Gap”. Toxicol. Sci. 167, 307–321 (2019).

2. Moggs, J. et al. Investigative safety science as a competitive advantage for Pharma. Expert Opin. Drug Metab. 8, 1071–1082 (2012).

3. Beilmann, M. et al. Optimizing drug discovery by investigative toxicology: current and future trends. ALTEX 36, 289–313 (2019).

4. ICH Topic -M3 (R2): Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals (European Medicines Agency, 2009).

5. Roberts, R. A. Understanding drug targets: no such thing as bad news. Drug Discov. Today 23, 1925–1928 (2018).

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