Delivering on the promise of protein degraders
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-023-00652-2.pdf
Reference136 articles.
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3. Churcher, I. Protac-induced protein degradation in drug discovery: breaking the rules or just making new ones? J. Med. Chem. 61, 444–452 (2018).
4. Maple, H. J., Clayden, N., Baron, A., Stacey, C. & Felix, R. Developing degraders: principles and perspectives on design and chemical space. MedChemComm 10, 1755–1764 (2019).
5. Pettersson, M. & Crews, C. M. Proteolysis targeting chimeras (PROTACs) — past, present and future. Drug Discov. Today Technol. 31, 15–27 (2019).
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