Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations

Author:

Wu Chen,Hu Zhibin,He Zhonghu,Jia Weihua,Wang Feng,Zhou Yifeng,Liu Zhihua,Zhan Qimin,Liu Yu,Yu Dianke,Zhai Kan,Chang Jiang,Qiao Yan,Jin Guangfu,Liu Zhe,Shen Yuanyuan,Guo Chuanhai,Fu Jianhua,Miao Xiaoping,Tan Wen,Shen Hongbing,Ke Yang,Zeng Yixin,Wu Tangchun,Lin Dongxin

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference32 articles.

1. Song, C., Xing, D., Tan, W., Wei, Q. & Lin, D. Methylenetetrahydrofolate reductase polymorphisms increases risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res. 61, 3272–3275 (2001).

2. Sun, T. et al. Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma. J. Natl. Cancer Inst. 96, 1030–1036 (2004).

3. Zhang, X. et al. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology 129, 565–576 (2005).

4. Sun, T. et al. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat. Genet. 39, 605–613 (2007).

5. Cui, R. et al. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology 137, 1768–1775 (2009).

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