Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency-Reference-Cited by-同舟云学术

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Published:2013-10-28 Issue:1 Volume:15 Page:88-97
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Lucas Carrie L,Kuehn Hye Sun,Zhao Fang,Niemela Julie E,Deenick Elissa K,Palendira Umaimainthan,Avery Danielle T,Moens Leen,Cannons Jennifer L,Biancalana Matthew,Stoddard Jennifer,Ouyang Weiming,Frucht David M,Rao V Koneti,Atkinson T Prescott,Agharahimi Anahita,Hussey Ashleigh A,Folio Les R,Olivier Kenneth N,Fleisher Thomas A,Pittaluga Stefania,Holland Steven M,Cohen Jeffrey I,Oliveira Joao B,Tangye Stuart G,Schwartzberg Pamela L,Lenardo Michael J,Uzel Gulbu

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/ni.2771.pdf

Reference51 articles.

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2. Hemmings, B.A. & Restuccia, D.F. PI3K-PKB/Akt pathway. Cold Spring Harb. Perspect. Biol. 4, a011189 (2012).

3. Chantry, D. et al. p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272, 19236–19241 (1997).

4. Vanhaesebroeck, B. et al. P110δ, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. USA 94, 4330–4335 (1997).

5. Huang, C.H. et al. The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations. Science 318, 1744–1748 (2007).

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