Axon degeneration mechanisms: commonality amid diversity
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn1788.pdf
Reference122 articles.
1. Ferri, A., Sanes, J. R., Coleman, M. P., Cunningham, J. M. & Kato, A. C. Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr. Biol. 13, 669–673 (2003). Together with references 27 and 28, this paper definitively linked the mechanisms of Wallerian degeneration and 'dying back' neuropathy.
2. Fischer, L. R. et al. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185, 232–240 (2004).
3. Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282–1288 (2005). A provocative paper showing that blocking axonal transport worsens symptoms in a mouse model of Alzheimer's disease. Results also suggested that axonal spheroids may be sites of APP processing into Aβ.
4. Li, H., Li, S. H., Yu, Z. X., Shelbourne, P. & Li, X. J. Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice. J. Neurosci. 21, 8473–8481 (2001).
5. Libby, R. T. et al. Susceptibility to neurodegeneration in glaucoma is modified by Bax gene dosage. PLoS Genet. 1, e4 (2005).
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