Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
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Published:2020-04-27
Issue:5
Volume:26
Page:720-731
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Donovan Laura K., Delaidelli Alberto, Joseph Sujith K., Bielamowicz Kevin, Fousek KristenORCID, Holgado Borja L., Manno Alex, Srikanthan Dilakshan, Gad Ahmed Z.ORCID, Van Ommeren RandyORCID, Przelicki David, Richman Cory, Ramaswamy VijayORCID, Daniels Craig, Pallota Jonelle G., Douglas Tajana, Joynt Alyssa C. M., Haapasalo Joonas, Nor Carolina, Vladoiu Maria C., Kuzan-Fischer Claudia M., Garzia Livia, Mack Stephen C., Varadharajan SrinidhiORCID, Baker Matthew L., Hendrikse LiamORCID, Ly Michelle, Kharas Kaitlin, Balin Polina, Wu Xiaochong, Qin Lei, Huang Ning, Stucklin Ana GuerreiroORCID, Morrissy A. SoranaORCID, Cavalli Florence M. G., Luu Betty, Suarez Raul, De Antonellis Pasqualino, Michealraj Antony, Rastan Avesta, Hegde Meenakshi, Komosa Martin, Sirbu Olga, Kumar Sachin A.ORCID, Abdullaev Zied, Faria Claudia C., Yip StephenORCID, Hukin JulietteORCID, Tabori Uri, Hawkins Cynthia, Aldape Ken, Daugaard MadsORCID, Maris John M., Sorensen Poul H., Ahmed NabilORCID, Taylor Michael D.ORCID
Funder
EIF | Stand Up To Cancer DH | NIHR | Programme Development Grants Stand Up To Cancer - St Baldrick’s Foundation Paediatric Immunotherapy Dream Team.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference59 articles.
1. Pui, C. H., Gajjar, A. J., Kane, J. R., Qaddoumi, I. A. & Pappo, A. S. Challenging issues in pediatric oncology. Nat. Rev. Clin. Oncol. 8, 540–549 (2011). 2. Vladoiu, M. C. et al. Childhood cerebellar tumors mirror conserved fetal transcriptional programs. Nature 572, 67–73 (2019). 3. Mack, S. C. et al. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature 553, 101–105 (2018). 4. Khatua, S., Ramaswamy, V. & Bouffet, E. Current therapy and the evolving molecular landscape of paediatric ependymoma. Eur. J. Cancer 70, 34–41 (2017). 5. Ramaswamy, V. et al. Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. Lancet Oncol. 14, 1200–1207 (2013).
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