Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease-Reference-Cited by-同舟云学术

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Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

Published:2020-06-22 Issue:8 Volume:26 Page:1256-1263
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Dujardin Simon^ORCID,Commins Caitlin,Lathuiliere Aurelien,Beerepoot Pieter^ORCID,Fernandes Analiese R.,Kamath Tarun V.,De Los Santos Mark B.^ORCID,Klickstein Naomi,Corjuc Diana L.,Corjuc Bianca T.,Dooley Patrick M.,Viode Arthur,Oakley Derek H.,Moore Benjamin D.,Mullin Kristina,Jean-Gilles Dinorah,Clark Ryan,Atchison Kevin,Moore Renee,Chibnik Lori B.,Tanzi Rudolph E.^ORCID,Frosch Matthew P.,Serrano-Pozo Alberto^ORCID,Elwood Fiona,Steen Judith A.,Kennedy Matthew E.,Hyman Bradley T.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Aging

JPB Foundation

The Tau consortium

Alzheimer’s Association

the Martin L. and Sylvia Seevak Hoffman Fellowship for Alzheimer’s research

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Cure Alzheimer’s Fund

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-020-0938-9.pdf

Reference56 articles.

1. Komarova, N. L. & Thalhauser, C. J. High degree of heterogeneity in Alzheimer’s disease progression patterns. PLoS Comput. Biol. 7, e1002251 (2011).

2. Giannakopoulos, P. et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease. Neurology 60, 1495–1500 (2003).

3. Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T. & Hyman, B. T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42, 631–639 (1992).

4. Arakhamia, T. et al. Posttranslational modifications mediate the structural diversity of tauopathy strains. Cell 180, 633–644 e612 (2020).

5. Falcon, B. et al. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature 568, 420–423 (2019).

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