A rectal cancer organoid platform to study individual responses to chemoradiation
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Published:2019-10
Issue:10
Volume:25
Page:1607-1614
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Ganesh Karuna, Wu Chao, O’Rourke Kevin P., Szeglin Bryan C.ORCID, Zheng Youyun, Sauvé Charles-Etienne Gabriel, Adileh Mohammad, Wasserman Isaac, Marco Michael R., Kim Amanda S., Shady Maha, Sanchez-Vega Francisco, Karthaus Wouter R., Won Helen H., Choi Seo-Hyun, Pelossof Raphael, Barlas Afsar, Ntiamoah Peter, Pappou Emmanouil, Elghouayel Arthur, Strong James S., Chen Chin-Tung, Harris Jennifer W., Weiser Martin R., Nash Garrett M., Guillem Jose G., Wei Iris H., Kolesnick Richard N., Veeraraghavan HariniORCID, Ortiz Eduardo J., Petkovska Iva, Cercek Andrea, Manova-Todorova Katia O., Saltz Leonard B., Lavery Jessica A.ORCID, DeMatteo Ronald P., Massagué Joan, Paty Philip B., Yaeger Rona, Chen Xi, Patil Sujata, Clevers HansORCID, Berger Michael F., Lowe Scott W.ORCID, Shia JinruORCID, Romesser Paul B., Dow Lukas E., Garcia-Aguilar JulioORCID, Sawyers Charles L.ORCID, Smith J. JoshuaORCID
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference46 articles.
1. Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2019. Ca. Cancer J. Clin. 69, 7–34 (2019). 2. Benson, A.B. et al. NCCN Guidelines, Version 2.2019. Rectal Cancer. National Comprehensive Cancer Network (2019). 3. Smith, J. J. et al. Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncol. 5, e185896 (2019). 4. van der Valk, M. J. M. et al. Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study. Lancet 391, 2537–2545 (2018). 5. Martens, M. H. et al. Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer. J. Natl Cancer Inst. 108, djw171 (2016).
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