Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

Author:

Theruvath Johanna,Menard Marie,Smith Benjamin A. H.ORCID,Linde Miles H.ORCID,Coles Garry L.,Dalton Guillermo Nicolas,Wu Wei,Kiru Louise,Delaidelli Alberto,Sotillo Elena,Silberstein John L.,Geraghty Anna C.,Banuelos Allison,Radosevich Molly Thomas,Dhingra Shaurya,Heitzeneder Sabine,Tousley Aidan,Lattin John,Xu Peng,Huang Jing,Nasholm Nicole,He Andy,Kuo Tracy C.ORCID,Sangalang Emma R. B.,Pons Jaume,Barkal Amira,Brewer Rachel E.,Marjon Kristopher D.,Vilches-Moure Jose G.,Marshall Payton L.,Fernandes Ricardo,Monje MichelleORCID,Cochran Jennifer R.ORCID,Sorensen Poul H.ORCID,Daldrup-Link Heike E.ORCID,Weissman Irving L.ORCID,Sage JulienORCID,Majeti RavindraORCID,Bertozzi Carolyn R.ORCID,Weiss William A.ORCID,Mackall Crystal L.ORCID,Majzner Robbie G.ORCID

Funder

Alex’s Lemonade Stand Foundation for Childhood Cancer

Deutsche Krebshilfe

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference67 articles.

1. Schulz, G. et al. Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res. 44, 5914–5920 (1984).

2. Long, A. H. et al. Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer Immunol. Res. 4, 869–880 (2016).

3. Dobrenkov, K., Ostrovnaya, I., Gu, J., Cheung, I. Y. & Cheung, N. K. Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults. Pediatr. Blood Cancer 63, 1780–1785 (2016).

4. Mount, C. W. et al. Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas. Nat. Med. 24, 572–579 (2018).

5. Cheresh, D. A., Rosenberg, J., Mujoo, K., Hirschowitz, L. & Reisfeld, R. A. Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis. Cancer Res. 46, 5112–5118 (1986).

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