Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
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Published:2023-06
Issue:6
Volume:29
Page:1389-1399
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Magen AssafORCID, Hamon Pauline, Fiaschi Nathalie, Soong Brian Y., Park Matthew D., Mattiuz RaphaëlORCID, Humblin Etienne, Troncoso LeannaORCID, D’souza Darwin, Dawson TravisORCID, Kim Joel, Hamel Steven, Buckup Mark, Chang Christie, Tabachnikova Alexandra, Schwartz Hara, Malissen Nausicaa, Lavin Yonit, Soares-Schanoski Alessandra, Giotti Bruno, Hegde Samarth, Ioannou Giorgio, Gonzalez-Kozlova EdgarORCID, Hennequin Clotilde, Le Berichel Jessica, Zhao Zhen, Ward Stephen C., Fiel Isabel, Kou Baijun, Dobosz Michael, Li Lianjie, Adler Christina, Ni Min, Wei Yi, Wang Wei, Atwal Gurinder S., Kundu Kunal, Cygan Kamil J.ORCID, Tsankov Alexander M., Rahman Adeeb, Price Colles, Fernandez Nicolas, He Jiang, Gupta Namita T.ORCID, Kim-Schulze Seunghee, Gnjatic SachaORCID, Kenigsberg EphraimORCID, Deering Raquel P., Schwartz MyronORCID, Marron Thomas U.ORCID, Thurston GavinORCID, Kamphorst Alice O., Merad MiriamORCID
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference72 articles.
1. Tabrizian, P., Jibara, G., Shrager, B., Schwartz, M. & Roayaie, S. Recurrence of hepatocellular cancer after resection: patterns, treatments, and prognosis. Ann. Surg. 261, 947–955 (2015). 2. Shindoh, J. et al. Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma. HPB (Oxford) 15, 31–39 (2013). 3. Chalabi, M. et al. Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers. Nat. Med. 26, 566–576 (2020). 4. Forde, P. M. et al. Neoadjuvant PD-1 blockade in resectable lung cancer. N. Engl. J. Med. 378, 1976–1986 (2018). 5. Huang, A. C. et al. A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma. Nat. Med. 25, 454–461 (2019).
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