Effects of urban living environments on mental health in adults
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Published:2023-06
Issue:6
Volume:29
Page:1456-1467
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Xu JiayuanORCID, Liu Nana, Polemiti ElliORCID, Garcia-Mondragon LilianaORCID, Tang Jie, Liu Xiaoxuan, Lett TristramORCID, Yu LeORCID, Nöthen Markus M.ORCID, Feng JianfengORCID, Yu ChunshuiORCID, Marquand Andre, Schumann GunterORCID, Walter Henrik, Heinz Andreas, Ralser Markus, Twardziok Sven, Vaidya Nilakshi, Serin Emin, Jentsch Marcel, Hitchen Esther, Eils Roland, Taron Ulrike-Helene, Schütz Tatjana, Schepanski Kerstin, Banks Jamie, Banaschewski Tobias, Jansone Karina, Christmann Nina, Meyer-Lindenberg Andreas, Tost Heike, Holz Nathalie, Schwarz Emanuel, Stringaris Argyris, Neidhart Maja, Nees Frauke, Siehl Sebastian, A. Andreassen Ole, T. Westlye Lars, van der Meer Dennis, Fernandez Sara, Kjelkenes Rikka, Ask Helga, Rapp Michael, Tschorn Mira, Böttger Sarah Jane, Novarino Gaia, Marr Lena, Slater Mel, Viapiana Guillem Feixas, Orosa Francisco Eiroa, Gallego Jaime, Pastor Alvaro, Forstner Andreas, Hoffmann Per, M. Nöthen Markus, J. Forstner Andreas, Claus Isabelle, Miller Abbi, Heilmann-Heimbach Stefanie, Sommer Peter, Boye Mona, Wilbertz Johannes, Schmitt Karen, Jirsa Viktor, Petkoski Spase, Pitel Séverine, Otten Lisa, Athanasiadis Anastasios-Polykarpos, Pearmund Charlie, Spanlang Bernhard, Alvarez Elena, Sanchez Mavi, Giner Arantxa, Hese Sören, Renner Paul, Jia Tianye, Gong Yanting, Xia Yunman, Chang Xiao, Calhoun Vince, Liu Jingyu, Thompson Paul, Clinton Nicholas, Desrivieres Sylvane, H. Young Allan, Stahl Bernd, Ogoh George,
Abstract
AbstractUrban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference66 articles.
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