Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration
Author:
Publisher
Springer Science and Business Media LLC
Subject
Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry
Link
http://www.nature.com/articles/s12276-018-0173-3.pdf
Reference34 articles.
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2. Vergroesen, P. P. et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthr. Cartil. 23, 1057–1070 (2015).
3. Fontana, G., See, E. & Pandit, A. Current trends in biologics delivery to restore intervertebral disc anabolism. Adv. Drug Deliv. Rev. 84, 146–158 (2015).
4. Dimozi, A., Mavrogonatou, E., Sklirou, A. & Kletsas, D. Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells. Eur. Cell Mater. 30, 89–102 (2015). discussion 3.
5. Chen, D. et al. Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. Cell Death Dis. 7, e2441 (2016).
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