Author:
Zhuang Hai-Hui,Qu Qiang,Teng Xin-Qi,Dai Ying-Huan,Qu Jian
Abstract
AbstractTranscriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in the majority of brain tumors, including adult glioblastoma and pediatric brain tumors. Epigenetic abnormalities can activate epigenetic regulatory elements to regulate the expression of oncogenes. Superenhancers (SEs), identified as novel epigenetic regulatory elements, are clusters of enhancers with cell-type specificity that can drive the aberrant transcription of oncogenes and promote tumor initiation and progression. As gene regulators, SEs are involved in tumorigenesis in a variety of tumors, including brain tumors. SEs are susceptible to inhibition by their key components, such as bromodomain protein 4 and cyclin-dependent kinase 7, providing new opportunities for antitumor therapy. In this review, we summarized the characteristics and identification, unique organizational structures, and activation mechanisms of SEs in tumors, as well as the clinical applications related to SEs in tumor therapy and prognostication. Based on a review of the literature, we discussed the relationship between SEs and different brain tumors and potential therapeutic targets, focusing on glioblastoma.
Publisher
Springer Science and Business Media LLC
Subject
Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry
Reference204 articles.
1. Miranda-Filho, A., Piñeros, M., Soerjomataram, I., Deltour, I. & Bray, F. Cancers of the brain and CNS: global patterns and trends in incidence. Neuro. Oncol. 19, 270–280 (2017).
2. Ostrom, Q. T., Francis, S. S. & Barnholtz-Sloan, J. S. Epidemiology of brain and other CNS tumors. Curr. Neurol. Neurosci. Rep. 21, 68 (2021).
3. Mo, F., Pellerino, A., Soffietti, R. & Rudà, R. Blood-brain barrier in brain tumors: biology and clinical relevance. Int. J. Mol. Sci. 22, 12654 (2021).
4. Steeg, P. S. The blood-tumour barrier in cancer biology and therapy. Nat. Rev. Clin. Oncol. 18, 696–714 (2021).
5. Gusyatiner, O. & Hegi, M. E. Glioma epigenetics: from subclassification to novel treatment options. Semin. Cancer Biol. 51, 50–58 (2018).
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