Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL-Reference-Cited by-同舟云学术

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Published:2002-06 Issue:6892 Volume:417 Page:975-978
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Hon Wai-Ching,Wilson Michael I.,Harlos Karl,Claridge Timothy D. W.,Schofield Christopher J.,Pugh Christopher W.,Maxwell Patrick H.,Ratcliffe Peter J.,Stuart David I.,Jones E. Yvonne

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature00767.pdf

Reference29 articles.

1. Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510–5514 (1995)

2. Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271–275 (1999)

3. Ohh, M. et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nature Cell Biol. 2, 423–427 (2000)

4. Ivan, M. et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464–468 (2001)

5. Jaakkola, P. et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468–472 (2001)

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