Bringing genome-wide association findings into clinical use
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3523.pdf
Reference94 articles.
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3. Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747–753 (2009).
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5. Jakobsdottir, J., Gorin, M. B., Conley, Y. P., Ferrell, R. E. & Weeks, D. E. Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet. 5, e1000337 (2009). This is a review of the predictive ability of strongly associated GWAS-defined SNPs in four diseases, demonstrating that high odds ratios (>50) are needed to improve prediction.
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