Cell cycle kinases as therapeutic targets for cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2907.pdf
Reference184 articles.
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4. Santamaria, D. et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811–815 (2007). This study showed that genetic ablation of the mitotic kinase CDK1, but not the interphase kinases CDK2, CDK4 and CDK6, causes cell cycle arrest and is lethal to mouse embryos.
5. Barr, A. R. & Gergely, F. Aurora-A: the maker and breaker of spindle poles. J. Cell Sci. 120, 2987–2996 (2007).
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