High-throughput crystallography for lead discovery in drug design
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd706.pdf
Reference75 articles.
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3. Whittle, P. J. & Blundell, T. L. Protein structure-based drug design. Annu. Rev. Biophys. Biomol. Struct. 23, 349375 (1994).A discussion of structure-based lead optimization, describing approaches developed over the previous decade and some of the successes.
4. Blundell, T. L. Structure-based drug design. Nature 384, S23S26 (1996).
5. Greer, J., Erickson, J. W., Baldwin, J. J. & Varney, M. D. Application of the three-dimensional structures of protein target molecules in structure-based drug design. J. Med. Chem. 37, 10351054 (1994).
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