PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms14610.pdf
Reference41 articles.
1. Feingold, K. R. & Elias, P. M. Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochim. Biophys. Acta 1841, 280–294 (2014).
2. van Smeden, J., Janssens, M., Gooris, G. S. & Bouwstra, J. A. The important role of stratum corneum lipids for the cutaneous barrier function. Biochim. Biophys. Acta 1841, 295–313 (2014).
3. Uchida, Y. & Holleran, W. M. Omega-O-acylceramide, a lipid essential for mammalian survival. J. Dermatol. Sci. 51, 77–87 (2008).
4. Mizutani, Y., Mitsutake, S., Tsuji, K., Kihara, A. & Igarashi, Y. Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie 91, 784–790 (2009).
5. Breiden, B. & Sandhoff, K. The role of sphingolipid metabolism in cutaneous permeability barrier formation. Biochim. Biophys. Acta 1841, 441–452 (2014).
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