Abstract
AbstractMany studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Reference43 articles.
1. Minaya Flores, P., Berbis, J., Chinot, O. & Auquier, P. Assessing the quality of life among caregivers of patients with gliomas. Neurooncol. Pract. 1, 191–197 (2014).
2. Hegi, M. E. & Stupp, R. Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter–still a dilemma? Neuro Oncol. 17, 1425–1427 (2015).
3. Patil, N. et al. Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000–2017. Neuro Oncol. noaa295 (2020).
4. Zhu, H., Yu, X., Zhang, S. & Shu, K. Targeting the complement pathway in malignant glioma microenvironments. Front. Cell Dev. Biol. 9, 657472 (2021).
5. Di Timoteo, G., Rossi, F. & Bozzoni, I. Circular RNAs in cell differentiation and development. Development 147, dev.182725 (2020).
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献