Development of αβ T cells in the human thymus
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri913.pdf
Reference156 articles.
1. Markert, M. L. et al. Transplantation of thymus tissue in complete DiGeorge syndrome. N. Engl. J. Med. 341, 1180–1189 (1999).This paper shows that the transplantation of thymi of young children into patients suffering from complete DiGeorge syndrome results in the appearance of mature T cells. This not only describes a much-needed therapeutic intervention for these patients, but also conclusively shows the essential role of the thymus for T-cell development in humans.
2. Miller, J. F. A. P. Immunological function of the thymus. Lancet 2, 748–749 (1961).
3. Heemskerk, M. H. et al. Inhibition of T-cell and promotion of natural-killer-cell development by the dominant-negative helix-loop-helix factor Id3. J. Exp. Med. 186, 1597–1602 (1997).This is the first paper to show in vitro genetic manipulation of human T-cell development. It shows that overexpression of ID3 in thymic precursors inhibits T-cell development, but stimulates NK-cell development. The data in this paper and those presented in reference 26 indicate that the balance between E- and ID-protein activities determines T-cell versus NK-cell fate.
4. Verhasselt, B. S. M., Verhelst, D. R., Naessens, E. & Plum, J. Retrovirally transduced CD34++ human cord-blood cells generate T cells expressing high levels of the retroviral encoded green fluorescent protein marker in vitro. Blood 91, 431–440 (1998).
5. Fischer, A. et al. Naturally occurring primary deficiencies of the immune system. Annu. Rev. Immunol. 15, 93–124 (1997).An excellent review that includes discussions about the effects of gene deficiencies on T-cell development in humans.
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