Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D
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Published:2024-01-18
Issue:1
Volume:14
Page:
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ISSN:2158-3188
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Container-title:Translational Psychiatry
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language:en
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Short-container-title:Transl Psychiatry
Author:
Hatzimanolis AlexORCID, Tosato SarahORCID, Ruggeri Mirella, Cristofalo Doriana, Mantonakis Leonidas, Xenaki Lida-Alkisti, Dimitrakopoulos Stefanos, Selakovic Mirjana, Foteli Stefania, Kosteletos Ioannis, Vlachos Ilias, Soldatos Rigas-FilipposORCID, Nianiakas Nikos, Ralli Irene, Kollias Konstantinos, Ntigrintaki Angeliki-Aikaterini, Stefanatou PentagiotissaORCID, Murray Robin M.ORCID, Vassos EvangelosORCID, Stefanis Nikos C.
Abstract
AbstractInsufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related alterations in lifestyle habits. Lower vitamin D has also been associated with adverse neurodevelopmental outcomes and predominant negative psychotic symptoms. This study aimed to investigate the contribution of polygenic risk score for circulating 25-hydroxyvitamin D concentration (PRS-vitD) to symptom presentation among individuals with FEP enrolled in the Athens First-Episode Psychosis Research Study (AthensFEP n = 205) and the Psychosis Incident Cohort Outcome Study (PICOS n = 123). The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale at baseline and follow-up assessments (AthensFEP: 4-weeks follow-up, PICOS: 1-year follow-up). Premorbid intelligence and adjustment domains were also examined as proxy measures of neurodevelopmental deviations. An inverse association between PRS-vitD and severity of negative symptoms, in particular lack of social motivation, was detected in the AthensFEP at baseline (adjusted R2 = 0.04, p < 0.001) and follow-up (adjusted R2 = 0.03, p < 0.01). The above observation was independently validated in PICOS at follow-up (adjusted R2 = 0.06, p < 0.01). No evidence emerged for a relationship between PRS-vitD and premorbid measures of intelligence and adjustment, likely not supporting an impact of lower PRS-vitD on developmental trajectories related to psychotic illness. These findings suggest that polygenic vulnerability to reduced vitamin D impairs motivation and social interaction in individuals with FEP, thereby interventions that encourage outdoor activities and social engagement in this patient group might attenuate enduring negative symptoms.
Funder
Theodore-Theohari Cozzika Foundation, Athens, Greece Italian Ministry of Health, Verona, Italy; Cariverona Foundation, Verona, Italy South London and Maudsley NHS Foundation Trust Kings College London
Publisher
Springer Science and Business Media LLC
Subject
Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health
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