Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters
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Published:2020-10-08
Issue:1
Volume:10
Page:
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ISSN:2158-3188
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Container-title:Translational Psychiatry
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language:en
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Short-container-title:Transl Psychiatry
Author:
Bruin Willem B.ORCID, Taylor Luke, Thomas Rajat M., Shock Jonathan P.ORCID, Zhutovsky PaulORCID, Abe YoshinariORCID, Alonso Pino, Ameis Stephanie H., Anticevic Alan, Arnold Paul D.ORCID, Assogna Francesca, Benedetti FrancescoORCID, Beucke Jan C., Boedhoe Premika S. W., Bollettini Irene, Bose Anushree, Brem Silvia, Brennan Brian P., Buitelaar Jan K.ORCID, Calvo RosaORCID, Cheng Yuqi, Cho Kang Ik K., Dallaspezia Sara, Denys DamiaanORCID, Ely Benjamin A.ORCID, Feusner Jamie D., Fitzgerald Kate D., Fouche Jean-Paul, Fridgeirsson Egill A., Gruner Patricia, Gürsel Deniz A., Hauser Tobias U.ORCID, Hirano YoshiyukiORCID, Hoexter Marcelo Q., Hu Hao, Huyser ChaimORCID, Ivanov Iliyan, James AnthonyORCID, Jaspers-Fayer Fern, Kathmann Norbert, Kaufmann Christian, Koch Kathrin, Kuno Masaru, Kvale Gerd, Kwon Jun SooORCID, Liu Yanni, Lochner Christine, Lázaro Luisa, Marques Paulo, Marsh Rachel, Martínez-Zalacaín Ignacio, Mataix-Cols David, Menchón José M.ORCID, Minuzzi Luciano, Moreira Pedro S., Morer Astrid, Morgado PedroORCID, Nakagawa Akiko, Nakamae TakashiORCID, Nakao Tomohiro, Narayanaswamy Janardhanan C., Nurmi Erika L., O’Neill Joseph, Pariente Jose C., Perriello Chris, Piacentini JohnORCID, Piras FabrizioORCID, Piras Federica, Reddy Y. C. Janardhan, Rus-Oswald Oana G.ORCID, Sakai YukiORCID, Sato João R., Schmaal LianneORCID, Shimizu Eiji, Simpson H. Blair, Soreni Noam, Soriano-Mas CarlesORCID, Spalletta Gianfranco, Stern Emily R., Stevens Michael C.ORCID, Stewart S. Evelyn, Szeszko Philip R., Tolin David F., Venkatasubramanian GanesanORCID, Wang ZhenORCID, Yun Je-YeonORCID, van Rooij Daan, Banaj Nerisa, Bargalló Nuria, Batistuzzo Marcelo C., Brandeis Daniel, Busatto Geraldo F., Calvo Anna, Ciullo Valentina, Drechsler Renate, Esteves Madalena, Falini Andrea, Fang Yu, Figee Martijn, Fontaine Martine, Gueguen Margot, Hamatani Sayo, Hanna Gregory L., Hansen Bjarne, Ikari Keisuke, Lázaro Luisa, Magalhães Ricardo, Masuda Yasutaka, Matsumoto Koji, Miguel Euripedes C., Morer Astrid, Pittenger Christopher, Poletti Sara, Sakai Yuki, Sousa Nuno, Takahashi Jumpei, Thorsen Anders L., Tsuchiyagaito Aki, Vecchio Daniela, Veltman Dick J., Walitza Susanne, Watanabe Anri, Xu Xiufeng, Xu Jian, Yamada Kei, Yoshida Tokiko, Zarei Mojtaba, Zhao Qing, Zhou Cong, de Vries Froukje E., de Wit Stella J., van Rooij Daan, van Wingen Guido A., van den Heuvel Odile A., van der Werf Ysbrand D., Thompson Paul M., van den Heuvel Odile A., Stein Dan J.ORCID, van Wingen Guido A.ORCID,
Abstract
AbstractNo diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
Funder
MEXT | Japan Society for the Promotion of Science Ministry of Economy and Competitiveness | Instituto de Salud Carlos III Alberta Innovates Ontario Brain Institute Hartmann Müller-Stiftung für Medizinische Forschung U.S. Department of Health & Human Services | NIH | National Institute of Mental Health National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund Dana Foundation International OCD Foundation Brain and Behavior Research Foundation Jacobs Foundation Fundação de Amparo à Pesquisa do Estado de São Paulo U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse Michael Smith Foundation for Health Research Bundesministerium für Bildung und Forschung Deutsche Forschungsgemeinschaft Helse Vest National Research Foundation Fundació la Marató de TV3 Wellcome Trust South London and Maudsley NHS Foundation Trust Ministry of Education, Culture, Sports, Science and Technology Ministero della Salute Department of Health | National Health and Medical Research Council Provincial Health Services Authority DBT India Alliance Nederlandse Organisatie voor Wetenschappelijk Onderzoek Hersenstichting ZonMw
Publisher
Springer Science and Business Media LLC
Subject
Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health
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