Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis
Author:
Funder
National Natural Science Foundation of China
Department of Science and Technology of Sichuan Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
http://www.nature.com/articles/s41392-021-00528-0.pdf
Reference5 articles.
1. Buckley, L. & Humphrey, M. B. Glucocorticoid-induced osteoporosis. N. Engl. J. Med. 379, 2547–2556 (2018).
2. Li, C. et al. Programmed cell senescence in skeleton during late puberty. Nat. Commun. 8, 1312 (2017).
3. Farr, J. N. et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat. Med. 23, 1072–1079 (2017).
4. Zhou, B. O. et al. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154–168 (2014).
5. Oeseburg, H. et al. Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A. Arterioscler. Thromb. Vasc. Biol. 30, 1407–1414 (2010).
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