Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics
Link
https://www.nature.com/articles/s41392-021-00807-w.pdf
Reference5 articles.
1. Demaria, O. et al. Harnessing innate immunity in cancer therapy. Nature 574, 45–56 (2019).
2. Guerriero, J. L. Macrophages: the road less traveled, changing anticancer therapy. Trends Mol. Med. 24, 472–489 (2018).
3. Cappel, D. A. et al. Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA Cycle and redox metabolism in liver. Cell Metab. 29, 1291–1305.e1298 (2019).
4. Zhou, Z. et al. Perfluorocarbon nanoparticles mediated platelet blocking disrupt vascular barriers to improve the efficacy of oxygen-sensitive antitumor drugs. Small 14, e1801694 (2018).
5. DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19, 369–382 (2019).
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