Author:
Wang Zhaoqing,Xu Qingji,Zhang Nengwei,Du Xuemei,Xu Guangzhong,Yan Xiyun
Abstract
AbstractCD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as an adhesion molecule to mediate a homophilic adhesion through the direct interactions between CD146 and itself is still lacking. Recent evidence revealed that CD146 is not merely an adhesion molecule, but also a cellular surface receptor of miscellaneous ligands, including some growth factors and extracellular matrixes. Through the bidirectional interactions with its ligands, CD146 is actively involved in numerous physiological and pathological processes of cells. Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis. Thus, immunotherapy against CD146 would provide a promising strategy to inhibit metastasis, which accounts for the majority of cancer-associated deaths. Therefore, to deepen the understanding of CD146, we review the reports describing the newly identified ligands of CD146 and discuss the implications of these findings in establishing novel strategies for cancer therapy.
Funder
Ministry of Science and Technology of the People’s Republic of China
Natural Science Foundation of Beijing Municipality
The first grant is the National Key Technology Research and Development Program of the Ministry of Science and Technology of Chin
Publisher
Springer Science and Business Media LLC
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