Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats - pharmacokinetic/pharmacodynamic modelling

Author:

Bouw M René,Xie Rujia,Tunblad Karin,Hammarlund-Udenaes Margareta

Publisher

Wiley

Subject

Pharmacology

Reference35 articles.

1. Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling;AASMUNDSTAD;J. Pharmacol. Exp. Ther.,1995

2. Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats;ABBOTT;Life Sci.,1988

3. Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucuronide and other related opiates;AVDEEF;J. Med. Chem.,1996

4. BEAL , S.L. SHEINER , L.S. 1992 NONMEM user's guide-part VII. NONMEM Project Group University of California, San Francisco, CA

5. Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat;BICKEL;J. Pharmacol. Exp. Ther.,1996

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