Identification of circulating proteins associated with general cognitive function among middle-aged and older adults-Reference-Cited by-同舟云学术

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Published:2023-11-03 Issue:1 Volume:6 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Tin Adrienne^ORCID,Fohner Alison E.^ORCID,Yang Qiong^ORCID,Brody Jennifer A.,Davies Gail^ORCID,Yao Jie,Liu Dan,Caro Ilana^ORCID,Lindbohm Joni V.,Duggan Michael R.^ORCID,Meirelles Osorio,Harris Sarah E.^ORCID,Gudmundsdottir Valborg,Taylor Adele M.,Henry Albert,Beiser Alexa S.,Shojaie Ali,Coors Annabell^ORCID,Fitzpatrick Annette L.,Langenberg Claudia^ORCID,Satizabal Claudia L.,Sitlani Colleen M.,Wheeler Eleanor,Tucker-Drob Elliot M.^ORCID,Bressler Jan^ORCID,Coresh Josef^ORCID,Bis Joshua C.^ORCID,Candia Julián^ORCID,Jennings Lori L.^ORCID,Pietzner Maik^ORCID,Lathrop Mark,Lopez Oscar L.^ORCID,Redmond Paul,Gerszten Robert E.^ORCID,Rich Stephen S.^ORCID,Heckbert Susan R.^ORCID,Austin Thomas R.,Hughes Timothy M.,Tanaka Toshiko,Emilsson Valur^ORCID,Vasan Ramachandran S.,Guo Xiuqing^ORCID,Zhu Yineng,Tzourio Christophe,Rotter Jerome I.^ORCID,Walker Keenan A.^ORCID,Ferrucci Luigi^ORCID,Kivimäki Mika^ORCID,Breteler Monique M. B.^ORCID,Cox Simon R.^ORCID,Debette Stephanie^ORCID,Mosley Thomas H.,Gudnason Vilmundur G.^ORCID,Launer Lenore J.^ORCID,Psaty Bruce M.^ORCID,Seshadri Sudha^ORCID,Fornage Myriam^ORCID

Abstract

AbstractIdentifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer’s disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p < 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets.

Publisher

Springer Science and Business Media LLC

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.nature.com/articles/s42003-023-05454-1.pdf

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