Abstract
AbstractLive-attenuated measles virus (MeV) has been extraordinarily effective in preventing measles infections and their often deadly sequelae, accompanied by remarkable safety and stability since their first licensing in 1963. The advent of recombinant DNA technologies, combined with systems to generate infectious negative-strand RNA viruses on the basis of viral genomes encoded on plasmid DNA in the 1990s, paved the way to generate recombinant, vaccine strain-derived MeVs. These live-attenuated vaccine constructs can encode and express additional foreign antigens during transient virus replication following immunization. Effective humoral and cellular immune responses are induced not only against the MeV vector, but also against the foreign antigen cargo in immunized individuals, which can protect against the associated pathogen. This review aims to present an overview of the versatility of this vaccine vector as platform technology to target various diseases, as well as current research and developmental stages, with one vaccine candidate ready to enter phase III clinical trials to gain marketing authorization, MV-CHIK.
Funder
Bundesministerium für Gesundheit
Deutsche Forschungsgemeinschaft
Deutsches Zentrum für Infektionsforschung
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Infectious Diseases,Pharmacology,Immunology
Reference103 articles.
1. Naniche, D. Human immunology of measles virus infection. Curr. Top. Microbiol. Immunol. 330, 151–171 (2009).
2. Düx, A. et al. Measles virus and rinderpest virus divergence dated to the sixth century BCE. Science 368, 1367–1370 (2020).
3. Bankamp, B., Takeda, M., Zhang, Y., Xu, W. & Rota, P. A. Genetic characterization of measles vaccine strains. J. Infect. Dis. 204, S533–S548 (2011).
4. Tatsuo, H., Ono, N., Tanaka, K. & Yanagi, Y. SLAM (CDw150) is a cellular receptor for measles virus. Nature 406, 893–897 (2000).
5. Mühlebach, M. D. et al. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 480, 530–533 (2011).
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