A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

Author:

Cree Lynsey M,Samuels David C,de Sousa Lopes Susana Chuva,Rajasimha Harsha Karur,Wonnapinij Passorn,Mann Jeffrey R,Dahl Hans-Henrik M,Chinnery Patrick F

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference30 articles.

1. Holt, I.J., Miller, D.H. & Harding, A.E. Genetic heterogeneity and mitochondrial DNA heteroplasmy in Leber's hereditary optic neuropathy. J. Med. Genet. 26, 739–743 (1989).

2. Bolhuis, P.A. et al. Rapid shift on genotype of human mitochondrial DNA in a family with Leber's hereditary optic neuropathy. Biochem. Biophys. Res. Commun. 170, 994–997 (1990).

3. Vilkki, J., Savontaus, M.L. & Nikoskelainen, E.K. Segregation of mitochondrial genomes in a heteroplasmic lineage with Leber hereditary optic neuroretinopathy. Am. J. Hum. Genet. 47, 95–100 (1990).

4. Larsson, N.G. et al. Segregation and manifestations of the mtDNA tRNA(Lys) A → G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am. J. Hum. Genet. 51, 1201–1212 (1992).

5. Upholt, W.B. & Dawid, I.B. Mapping of mitochondrial DNA of individual sheep and goats: rapid evolution in the D loop region. Cell 11, 571–583 (1977).

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