αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep35006.pdf
Reference33 articles.
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2. Veillette, A., Bookman, M. A., Horak, E. M., Samelson, L. E. & Bolen, J. B. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338, 257–259 (1989).
3. Chalupny, N. J., Ledbetter, J. A. & Kavathas, P. Association of CD8 with p56lck is required for early T cell signaling events. EMBO J. 10, 1201–1207 (1991).
4. Van Laethem, F. et al. Deletion of CD4 and CD8 coreceptors permits generation of αβT cells that recognize antigens independently of the MHC. Immunity 27, 735–750 (2007).
5. Van Laethem, F. et al. Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154, 1326–1341 (2013).
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