CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations-Reference-Cited by-同舟云学术

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CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

Published:2008-09-15 Issue:1 Volume:28 Page:85-94
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Smalley K S M,Xiao M,Villanueva J,Nguyen T K,Flaherty K T,Letrero R,Van Belle P,Elder D E,Wang Y,Nathanson K L,Herlyn M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc2008362.pdf

Reference27 articles.

1. Chen J, Fujii K, Zhang L, Roberts T, Fu H . (2001). Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci USA 98: 7783–7788.

2. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417: 949–954.

3. Dhomen N, Marais R . (2007). New insight into BRAF mutations in cancer. Curr Opin Genet Dev 17: 31–39.

4. Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA et al. (2006). In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 66: 9483–9491.

5. Eisen T, Ahmad T, Flaherty KT, Gore M, Kaye S, Marais R et al. (2006). Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 95: 581–586.

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