Impact of oncogenic pathways on evasion of antitumour immune responses
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc.2017.117.pdf
Reference91 articles.
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3. Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23–34 (2015).
4. Le, D. T. et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357, 409–413 (2017).
5. Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568–571 (2014). This work provides proof that response to checkpoint blockade therapy (anti-PD1) is associated with the presence of T cells in the tumour microenvironment (TME) (T cell-inflamed phenotype).
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