Transport of drugs from blood vessels to tumour tissue

Author:

Dewhirst Mark W.,Secomb Timothy W.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference182 articles.

1. Bast, R. C. et al. Holland-Frei Cancer Medicine 9th edn (Wiley-Blackwell, 2017).

2. Swabb, E. A., Wei, J. & Gullino, P. M. Diffusion and convection in normal and neoplastic tissues. Cancer Res. 34, 2814–2822 (1974). In this early account of how tissue glycosaminoglycan content can affect solute transport by convection compared with by diffusion in tumours, the authors suggest that degradation of glycosaminoglycan with hyaluronidase could improve solute transport in tumours.

3. Jain, R. K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 6, 559–593 (1987). This comprehensive review discusses the transport properties of microvessel walls with respect to their importance for drugs of various sizes.

4. Jain, R. K. Transport of molecules in the tumor interstitium: a review. Cancer Res. 47, 3039–3051 (1987). This review focuses on factors that impede solute transport in the interstitium of tumours and shows how high IFP and lack of functioning lymphatics contribute to reduced transport.

5. Jain, R. K. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors. Microcirculation 4, 1–23 (1997).

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