A molecular glue degrader of eRF1 on the ribosome
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-023-01522-z.pdf
Reference5 articles.
1. Hellen, C. U. T. Translation termination and ribosome recycling in eukaryotes. Cold Spring Harb. Perspect. Biol. 10, a032656 (2018). A review article describing translation termination.
2. Spelier, S., van Doorn, E. P. M., van der Ent, C. K., Beekman, J. M. & Koppens, M. A. J. Readthrough compounds for nonsense mutations: bridging the translational gap. Trends Mol. Med. 29, 297–314 (2023). This review article descripes therapeutic strategies for diseases caused by nonsense mutations.
3. Sharma, J. et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat. Commun. 12, 4358 (2021). This article reports that SRI-41315 induces eRF1 degradation and enhances premature read-through of the stop codon.
4. Brown, A., Shao, S., Murray, J., Hegde, R. S. & Ramakrishnan, V. Structural basis for stop codon recognition in eukaryotes. Nature 524, 493–496 (2015). This article describes the isolation of translation termination complexes to reveal how eRF1 recognizes stop codons.
5. Oltion, K. et al. An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell 186, 346–362 (2023). This paper reports a cellular pathway that degrades translation factors aberrantly trapped on ribosomes.
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