Topoisomerase II and etoposide — a tangled tale
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41589-022-01236-8.pdf
Reference5 articles.
1. Baldwin, E. L. & Osheroff, N. Etoposide, topoisomerase II and cancer. Curr. Med. Chem. Anticancer Agents 5, 363–372 (2005). A review article on etoposide as a broadly used chemotherapeutic topo II poison.
2. Wu, C. C. et al. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science 333, 459–462 (2011). This paper reports the crystal structure of a DNA cleavage complex bound with etoposide.
3. Brower-Toland, B. D. et al. Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA. Proc. Natl Acad. Sci. USA 99, 1960–1965 (2002). This paper describes the DNA stretching methods to characterize interaction strengths and DNA release from bound proteins.
4. Le, T. T. et al. Mfd dynamically regulates transcription via a release and catch-up Mechanism. Cell 172, 344–357.e15 (2018). This paper describes the DNA unzipping mapper to characterize the strengths and locations of protein–DNA interactions.
5. Strick, T. R., Croquette, V. & Bensimon, D. Single-molecule analysis of DNA uncoiling by a type II topoisomerase. Nature 404, 901–904 (2000). This paper describes the use of magnetic tweezers for detecting topo II relaxation of DNA supercoiling.
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