The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression-Reference-Cited by-同舟云学术

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The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression

Published:2017-03-10 Issue:11 Volume:31 Page:2336-2346
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Abraham M,Klein S,Bulvik B,Wald H,Weiss I D,Olam D,Weiss L,Beider K,Eizenberg O,Wald O,Galun E,Avigdor A,Benjamini O,Nagler A,Pereg Y,Tavor S,Peled A

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

https://www.nature.com/articles/leu201782.pdf

Reference55 articles.

1. Peled A, Tavor S . Role of CXCR4 in the pathogenesis of acute myeloid leukemia. Theranostics 2013; 3: 34–39.

2. Estey E, Dohner H . Acute myeloid leukaemia. Lancet 2006; 368: 1894–1907.

3. Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med 2003; 9: 1158–1165.

4. Ayala F, Dewar R, Kieran M, Kalluri R . Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia 2009; 23: 2233–2241.

5. Burger JA, Peled A . CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 2009; 23: 43–52.

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