Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes
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Published:2021-11
Issue:11
Volume:53
Page:1534-1542
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Mansour Aly Dina, Dwivedi Om PrakashORCID, Prasad Rashmi B.ORCID, Käräjämäki Annemari, Hjort Rebecka, Thangam ManonanthiniORCID, Åkerlund Mikael, Mahajan Anubha, Udler Miriam S.ORCID, Florez Jose C.ORCID, McCarthy Mark I., Abecasis Goncalo, Baras Aris, Cantor Michael, Coppola Giovanni, Economides Aris, Lotta Luca A., Overton John D., Reid Jeffrey G., Shuldiner Alan, Beechert Christina, Forsythe Caitlin, Fuller Erin D., Gu Zhenhua, Lattari Michael, Lopez Alexander, Schleicher Thomas D., Padilla Maria Sotiropoulos, Widom Louis, Wolf Sarah E., Pradhan Manasi, Manoochehri Kia, Ulloa Ricardo H., Bai Xiaodong, Balasubramanian Suganthi, Blumenfeld Andrew, Eom Gisu, Habegger Lukas, Hawes Alicia, Khalid Shareef, Maxwell Evan K., Salerno William, Staples Jeffrey C., Jones Marcus B., Mitnaul Lyndon J., Brosnan Julia, Melander Olle, Carlsson Sofia, Hansson OlaORCID, Tuomi TiinamaijaORCID, Groop LeifORCID, Ahlqvist EmmaORCID, , , , ,
Publisher
Springer Science and Business Media LLC
Reference29 articles.
1. Ahlqvist, E. et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 6, 361–369 (2018). 2. Zaharia, O. P. et al. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol. 7, 684–694 (2019). 3. Dennis, J. M., Shields, B. M., Henley, W. E., Jones, A. G. & Hattersley, A. T. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol. 7, 442–451 (2019). 4. Bello-Chavolla, O. Y. et al. Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach. BMJ Open Diabetes Res. Care 8, e001550 (2020). 5. Rasouli, B. et al. Smoking and the risk of LADA: results from a Swedish population-based case-control study. Diabetes Care 39, 794–800 (2016).
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