Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
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Published:2021-09
Issue:9
Volume:53
Page:1300-1310
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Võsa UrmoORCID, Claringbould AnniqueORCID, Westra Harm-JanORCID, Bonder Marc Jan, Deelen PatrickORCID, Zeng Biao, Kirsten HolgerORCID, Saha Ashis, Kreuzhuber Roman, Yazar Seyhan, Brugge Harm, Oelen RoyORCID, de Vries Dylan H.ORCID, van der Wijst Monique G. P., Kasela Silva, Pervjakova Natalia, Alves IsabelORCID, Favé Marie-Julie, Agbessi Mawussé, Christiansen Mark W., Jansen RickORCID, Seppälä Ilkka, Tong Lin, Teumer AlexanderORCID, Schramm Katharina, Hemani Gibran, Verlouw JoostORCID, Yaghootkar Hanieh, Sönmez Flitman Reyhan, Brown AndrewORCID, Kukushkina Viktorija, Kalnapenkis Anette, Rüeger SinaORCID, Porcu EleonoraORCID, Kronberg Jaanika, Kettunen JohannesORCID, Lee Bernett, Zhang Futao, Qi Ting, Hernandez Jose AlquiciraORCID, Arindrarto Wibowo, Beutner Frank, ’t Hoen Peter A. C., van Meurs Joyce, van Dongen Jenny, van Iterson Maarten, Swertz Morris A., Jan Bonder Marc, Dmitrieva Julia, Elansary Mahmoud, Fairfax Benjamin P.ORCID, Georges MichelORCID, Heijmans Bastiaan T.ORCID, Hewitt Alex W.ORCID, Kähönen Mika, Kim Yungil, Knight Julian C.ORCID, Kovacs PeterORCID, Krohn KnutORCID, Li ShuangORCID, Loeffler Markus, Marigorta Urko M., Mei Hailang, Momozawa Yukihide, Müller-Nurasyid MartinaORCID, Nauck MatthiasORCID, Nivard Michel G.ORCID, Penninx Brenda W. J. H., Pritchard Jonathan K.ORCID, Raitakari Olli T., Rotzschke Olaf, Slagboom Eline P.ORCID, Stehouwer Coen D. A., Stumvoll Michael, Sullivan Patrick, ’t Hoen Peter A. C.ORCID, Thiery Joachim, Tönjes Anke, van Dongen JennyORCID, van Iterson Maarten, Veldink Jan H.ORCID, Völker UweORCID, Warmerdam RobertORCID, Wijmenga CiscaORCID, Swertz MorrisORCID, Andiappan AnandORCID, Montgomery Grant W.ORCID, Ripatti SamuliORCID, Perola Markus, Kutalik Zoltan, Dermitzakis EmmanouilORCID, Bergmann SvenORCID, Frayling TimothyORCID, van Meurs Joyce, Prokisch HolgerORCID, Ahsan Habibul, Pierce Brandon L., Lehtimäki Terho, Boomsma Dorret I.ORCID, Psaty Bruce M.ORCID, Gharib Sina A.ORCID, Awadalla Philip, Milani LiliORCID, Ouwehand Willem H.ORCID, Downes Kate, Stegle OliverORCID, Battle Alexis, Visscher Peter M.ORCID, Yang JianORCID, Scholz MarkusORCID, Powell Joseph, Gibson GregORCID, Esko TõnuORCID, Franke LudeORCID, ,
Publisher
Springer Science and Business Media LLC
Reference76 articles.
1. Yao, D. W., O’Connor, L. J., Price, A. L. & Gusev, A. Quantifying genetic effects on disease mediated by assayed gene expression levels. Nat. Genet. 52, 626–633 (2020). 2. O’Connor, L. J. et al. Extreme polygenicity of complex traits is explained by negative selection. Am. J. Hum. Genet. 105, 456–476 (2019). 3. Zeng, J. et al. Signatures of negative selection in the genetic architecture of human complex traits. Nat. Genet. 50, 746–753 (2018). 4. Westra, H. J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238–1243 (2013). 5. Kirsten, H. et al. Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci. Hum. Mol. Genet. 24, 4746–4763 (2015).
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