The trans-ancestral genomic architecture of glycemic traits
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Published:2021-05-31
Issue:6
Volume:53
Page:840-860
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Chen Ji, Spracklen Cassandra N., Marenne GaëlleORCID, Varshney ArushiORCID, Corbin Laura J.ORCID, Luan Jian’an, Willems Sara M., Wu Ying, Zhang Xiaoshuai, Horikoshi Momoko, Boutin Thibaud S., Mägi Reedik, Waage Johannes, Li-Gao Ruifang, Chan Kei Hang Katie, Yao Jie, Anasanti Mila D., Chu Audrey Y., Claringbould Annique, Heikkinen Jani, Hong Jaeyoung, Hottenga Jouke-Jan, Huo Shaofeng, Kaakinen Marika A., Louie Tin, März Winfried, Moreno-Macias Hortensia, Ndungu Anne, Nelson Sarah C., Nolte Ilja M., North Kari E., Raulerson Chelsea K., Ray Debashree, Rohde Rebecca, Rybin Denis, Schurmann Claudia, Sim Xueling, Southam Lorraine, Stewart Isobel D., Wang Carol A., Wang Yujie, Wu Peitao, Zhang Weihua, Ahluwalia Tarunveer S., Appel Emil V. R., Bielak Lawrence F., Brody Jennifer A., Burtt Noël P., Cabrera Claudia P., Cade Brian E., Chai Jin Fang, Chai Xiaoran, Chang Li-Ching, Chen Chien-Hsiun, Chen Brian H., Chitrala Kumaraswamy Naidu, Chiu Yen-Feng, de Haan Hugoline G., Delgado Graciela E., Demirkan Ayse, Duan Qing, Engmann Jorgen, Fatumo Segun A., Gayán Javier, Giulianini Franco, Gong Jung Ho, Gustafsson Stefan, Hai Yang, Hartwig Fernando P., He Jing, Heianza Yoriko, Huang Tao, Huerta-Chagoya Alicia, Hwang Mi Yeong, Jensen Richard A., Kawaguchi Takahisa, Kentistou Katherine A., Kim Young Jin, Kleber Marcus E., Kooner Ishminder K., Lai Shuiqing, Lange Leslie A., Langefeld Carl D., Lauzon Marie, Li Man, Ligthart Symen, Liu Jun, Loh Marie, Long Jirong, Lyssenko Valeriya, Mangino Massimo, Marzi Carola, Montasser May E., Nag Abhishek, Nakatochi Masahiro, Noce Damia, Noordam Raymond, Pistis Giorgio, Preuss Michael, Raffield Laura, Rasmussen-Torvik Laura J., Rich Stephen S., Robertson Neil R., Rueedi Rico, Ryan Kathleen, Sanna Serena, Saxena Richa, Schraut Katharina E., Sennblad Bengt, Setoh Kazuya, Smith Albert V., Sparsø Thomas, Strawbridge Rona J., Takeuchi Fumihiko, Tan Jingyi, Trompet Stella, van den Akker Erik, van der Most Peter J., Verweij Niek, Vogel Mandy, Wang Heming, Wang Chaolong, Wang Nan, Warren Helen R., Wen Wanqing, Wilsgaard Tom, Wong Andrew, Wood Andrew R., Xie Tian, Zafarmand Mohammad Hadi, Zhao Jing-Hua, Zhao Wei, Amin Najaf, Arzumanyan Zorayr, Astrup Arne, Bakker Stephan J. L., Baldassarre Damiano, Beekman Marian, Bergman Richard N., Bertoni Alain, Blüher Matthias, Bonnycastle Lori L., Bornstein Stefan R., Bowden Donald W., Cai Qiuyin, Campbell Archie, Campbell Harry, Chang Yi Cheng, de Geus Eco J. C., Dehghan Abbas, Du Shufa, Eiriksdottir Gudny, Farmaki Aliki Eleni, Frånberg Mattias, Fuchsberger Christian, Gao Yutang, Gjesing Anette P., Goel Anuj, Han Sohee, Hartman Catharina A., Herder Christian, Hicks Andrew A., Hsieh Chang-Hsun, Hsueh Willa A., Ichihara Sahoko, Igase Michiya, Ikram M. Arfan, Johnson W. Craig, Jørgensen Marit E., Joshi Peter K., Kalyani Rita R., Kandeel Fouad R., Katsuya Tomohiro, Khor Chiea Chuen, Kiess Wieland, Kolcic Ivana, Kuulasmaa Teemu, Kuusisto Johanna, Läll Kristi, Lam Kelvin, Lawlor Deborah A., Lee Nanette R., Lemaitre Rozenn N., Li Honglan, Lin Shih-Yi, Lindström Jaana, Linneberg Allan, Liu Jianjun, Lorenzo Carlos, Matsubara Tatsuaki, Matsuda Fumihiko, Mingrone Geltrude, Mooijaart Simon, Moon Sanghoon, Nabika Toru, Nadkarni Girish N., Nadler Jerry L., Nelis Mari, Neville Matt J., Norris Jill M., Ohyagi Yasumasa, Peters Annette, Peyser Patricia A., Polasek Ozren, Qi Qibin, Raven Dennis, Reilly Dermot F., Reiner Alex, Rivideneira Fernando, Roll Kathryn, Rudan Igor, Sabanayagam Charumathi, Sandow Kevin, Sattar Naveed, Schürmann Annette, Shi Jinxiu, Stringham Heather M., Taylor Kent D., Teslovich Tanya M., Thuesen Betina, Timmers Paul R. H. J., Tremoli Elena, Tsai Michael Y., Uitterlinden Andre, van Dam Rob M., van Heemst Diana, van Hylckama Vlieg Astrid, van Vliet-Ostaptchouk Jana V., Vangipurapu Jagadish, Vestergaard Henrik, Wang Tao, Willems van Dijk Ko, Zemunik Tatijana, Abecasis Gonçalo R., Adair Linda S., Aguilar-Salinas Carlos Alberto, Alarcón-Riquelme Marta E., An Ping, Aviles-Santa Larissa, Becker Diane M., Beilin Lawrence J., Bergmann Sven, Bisgaard Hans, Black Corri, Boehnke Michael, Boerwinkle Eric, Böhm Bernhard O., Bønnelykke Klaus, Boomsma D. I., Bottinger Erwin P., Buchanan Thomas A., Canouil Mickaël, Caulfield Mark J., Chambers John C., Chasman Daniel I., Chen Yii-Der Ida, Cheng Ching-Yu, Collins Francis S., Correa Adolfo, Cucca Francesco, de Silva H. Janaka, Dedoussis George, Elmståhl Sölve, Evans Michele K., Ferrannini Ele, Ferrucci Luigi, Florez Jose C., Franks Paul W., Frayling Timothy M., Froguel Philippe, Gigante Bruna, Goodarzi Mark O., Gordon-Larsen Penny, Grallert Harald, Grarup Niels, Grimsgaard Sameline, Groop Leif, Gudnason Vilmundur, Guo Xiuqing, Hamsten Anders, Hansen Torben, Hayward Caroline, Heckbert Susan R., Horta Bernardo L., Huang Wei, Ingelsson Erik, James Pankow S., Jarvelin Marjo-Ritta, Jonas Jost B., Jukema J. Wouter, Kaleebu Pontiano, Kaplan Robert, Kardia Sharon L. R., Kato Norihiro, Keinanen-Kiukaanniemi Sirkka M., Kim Bong-Jo, Kivimaki Mika, Koistinen Heikki A., Kooner Jaspal S., Körner Antje, Kovacs Peter, Kuh Diana, Kumari Meena, Kutalik Zoltan, Laakso Markku, Lakka Timo A., Launer Lenore J., Leander Karin, Li Huaixing, Lin Xu, Lind Lars, Lindgren Cecilia, Liu Simin, Loos Ruth J. F., Magnusson Patrik K. E., Mahajan Anubha, Metspalu Andres, Mook-Kanamori Dennis O., Mori Trevor A., Munroe Patricia B., Njølstad Inger, O’Connell Jeffrey R., Oldehinkel Albertine J., Ong Ken K., Padmanabhan Sandosh, Palmer Colin N. A., Palmer Nicholette D., Pedersen Oluf, Pennell Craig E., Porteous David J., Pramstaller Peter P., Province Michael A., Psaty Bruce M., Qi Lu, Raffel Leslie J., Rauramaa Rainer, Redline Susan, Ridker Paul M., Rosendaal Frits R., Saaristo Timo E., Sandhu Manjinder, Saramies Jouko, Schneiderman Neil, Schwarz Peter, Scott Laura J., Selvin Elizabeth, Sever Peter, Shu Xiao-ou, Slagboom P. Eline, Small Kerrin S., Smith Blair H., Snieder Harold, Sofer Tamar, Sørensen Thorkild I. A., Spector Tim D., Stanton Alice, Steves Claire J., Stumvoll Michael, Sun Liang, Tabara Yasuharu, Tai E. Shyong, Timpson Nicholas J., Tönjes Anke, Tuomilehto Jaakko, Tusie Teresa, Uusitupa Matti, van der Harst Pim, van Duijn Cornelia, Vitart Veronique, Vollenweider Peter, Vrijkotte Tanja G. M., Wagenknecht Lynne E., Walker Mark, Wang Ya X., Wareham Nick J., Watanabe Richard M., Watkins Hugh, Wei Wen B., Wickremasinghe Ananda R., Willemsen Gonneke, Wilson James F., Wong Tien-Yin, Wu Jer-Yuarn, Xiang Anny H., Yanek Lisa R., Yengo Loïc, Yokota Mitsuhiro, Zeggini Eleftheria, Zheng Wei, Zonderman Alan B., Rotter Jerome I., Gloyn Anna L., McCarthy Mark I., Dupuis Josée, Meigs James B., Scott Robert A., Prokopenko Inga, Leong Aaron, Liu Ching-Ti, Parker Stephen C. J.ORCID, Mohlke Karen L., Langenberg ClaudiaORCID, Wheeler EleanorORCID, Morris Andrew P.ORCID, Barroso InêsORCID, de Haan Hugoline G., van den Akker Erik, van der Most Peter J., de Geus Eco J. C., van Dam Rob M., van Heemst Diana, van Hylckama Vlieg Astrid, van Willems van Dijk Ko, de Silva H. Janaka, van der Harst Pim, van Duijn Cornelia, ,
Funder
There are too many different funders to enter one by one in the boxes. All funding information is contained in the Supplementary Note.
Publisher
Springer Science and Business Media LLC
Reference102 articles.
1. Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus: Abbreviated Report of a WHO Consultation Report No. WHO/NMH/CHP/CPM/11.1 (World Health Organization, 2011). 2. Goodarzi, M. O. et al. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am. J. Physiol. Endocrinol. Metab. 301, E402–E408 (2011). 3. Dimas, A. S. et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes 63, 2158–2171 (2014). 4. Udler, M. S. et al. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis. PLoS Med. 15, e1002654 (2018). 5. Udler, M. S., McCarthy, M. I., Florez, J. C. & Mahajan, A. Genetic risk scores for diabetes diagnosis and precision medicine. Endocr. Rev. 40, 1500–1520 (2019).
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