Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
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Published:2022-07-28
Issue:8
Volume:54
Page:1178-1191
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Hwang William L.ORCID, Jagadeesh Karthik A., Guo Jimmy A., Hoffman Hannah I., Yadollahpour PaymanORCID, Reeves Jason W., Mohan Rahul, Drokhlyansky Eugene, Van Wittenberghe Nicholas, Ashenberg Orr, Farhi Samouil L.ORCID, Schapiro DenisORCID, Divakar Prajan, Miller EricORCID, Zollinger Daniel R., Eng George, Schenkel Jason M., Su Jennifer, Shiau Carina, Yu Patrick, Freed-Pastor William A.ORCID, Abbondanza DomenicORCID, Mehta Arnav, Gould JoshuaORCID, Lambden Conner, Porter Caroline B. M., Tsankov Alexander, Dionne Danielle, Waldman Julia, Cuoco Michael S.ORCID, Nguyen Lan, Delorey ToniORCID, Phillips Devan, Barth Jaimie L., Kem Marina, Rodrigues Clifton, Ciprani Debora, Roldan JorgeORCID, Zelga PiotrORCID, Jorgji Vjola, Chen Jonathan H., Ely Zackery, Zhao Daniel, Fuhrman Kit, Fropf Robin, Beechem Joseph M., Loeffler Jay S., Ryan David P., Weekes Colin D., Ferrone Cristina R., Qadan Motaz, Aryee Martin J.ORCID, Jain Rakesh K.ORCID, Neuberg Donna S.ORCID, Wo Jennifer Y., Hong Theodore S., Xavier Ramnik, Aguirre Andrew J., Rozenblatt-Rosen OritORCID, Mino-Kenudson MariORCID, Castillo Carlos Fernandez-del, Liss Andrew S.ORCID, Ting David T.ORCID, Jacks TylerORCID, Regev AvivORCID
Funder
Ludwig Institute for Cancer Research Lustgarten Foundation
Publisher
Springer Science and Business Media LLC
Reference117 articles.
1. Versteijne, E. et al. Neoadjuvant chemoradiotherapy versus upfront surgery for resectable and borderline resectable pancreatic cancer: long-term results of the Dutch randomized PREOPANC trial. J. Clin. Oncol. 40, 1220–1230 (2022). 2. Mizrahi, J. D., Surana, R., Valle, J. W. & Schroff, R. T. Pancreatic cancer. Lancet 395, 2008–2020 (2020). 3. Collisson, E. A., Bailey, P., Chang, D. K. & Biankin, A. V. Molecular subtypes of pancreatic cancer. Nat. Rev. Gastroenterol. Hepatol. 16, 207–220 (2019). 4. Guo, J. A. et al. Refining the molecular framework for pancreatic cancer with single-cell and spatial technologies. Clin. Cancer Res. 27, 3825–3833 (2021). 5. Collisson, E. A. et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17, 500–503 (2011).
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