Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
-
Published:2021-03-29
Issue:4
Volume:53
Page:500-510
-
ISSN:1061-4036
-
Container-title:Nature Genetics
-
language:en
-
Short-container-title:Nat Genet
Author:
Wang LinORCID, Aschenbrenner DominikORCID, Zeng Zhiyang, Cao Xiya, Mayr Daniel, Mehta Meera, Capitani Melania, Warner NeilORCID, Pan Jie, Wang Liren, Li Qi, Zuo Tao, Cohen-Kedar Sarit, Lu Jiawei, Ardy Rico Chandra, Mulder Daniel J.ORCID, Dissanayake Dilan, Peng Kaiyue, Huang Zhiheng, Li Xiaoqin, Wang Yuesheng, Wang Xiaobing, Li Shuchao, Bullers Samuel, Gammage Anís N.ORCID, Warnatz Klaus, Schiefer Ana-Iris, Krivan Gergely, Goda Vera, Kahr Walter H. A.ORCID, Lemaire Mathieu, Griffin Helen R., Hambleton Sophie, Lu Chien-Yi, Siddiqui Iram, Surette Michael G.ORCID, Kotlarz Daniel, Engelhardt Karin R., Griffin Helen R., Rottapel Robert, Decaluwe Hélène, Laxer Ronald M., Proietti Michele, Hambleton SophieORCID, Elcombe Suzanne, Guo Cong-Hui, Grimbacher Bodo, Dotan Iris, Ng Siew C.ORCID, Freeman Spencer A., Snapper Scott B.ORCID, Klein ChristophORCID, Boztug Kaan, Huang YingORCID, Li DaliORCID, Uhlig Holm H., Muise Aleixo M.ORCID,
Publisher
Springer Science and Business Media LLC
Reference52 articles.
1. Mocsai, A., Ruland, J. & Tybulewicz, V. L. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat. Rev. Immunol. 10, 387–402 (2010). 2. Dennehy, K. M. et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur. J. Immunol. 38, 500–506 (2008). 3. Turner, M. et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378, 298–302 (1995). 4. Cheng, A. M. et al. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303–306 (1995). 5. Jakus, Z., Simon, E., Balazs, B. & Mocsai, A. Genetic deficiency of Syk protects mice from autoantibody-induced arthritis. Arthritis Rheum. 62, 1899–1910 (2010).
Cited by
55 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|