Adhesion G protein-coupled receptors in nervous system development and disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn.2016.86.pdf
Reference118 articles.
1. Bjarnadóttir, T. K. et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 84, 23–33 (2004).
2. Hamann, J. et al. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol. Rev. 67, 338–367 (2015).
3. Krasnoperov, V. G. et al. α-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18, 925–937 (1997). Biochemical screens were used to identify latrophilin 1 as the first known aGPCR in the nervous system.
4. Araç, D. et al. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 31, 1364–1378 (2012). This paper describes the structural and functional identification of the GAIN domain and demonstrates its general presence in aGPCRs and PKD1 proteins.
5. Lin, H. H. et al. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. J. Biol. Chem. 279, 31823–31832 (2004). Together with reference 4, this paper defined the mechanism underlying the autocatalytic cleavage at the GPS of aGPCRs.
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