Of mice and men—shedding new light on IL-13 activity in IBD
Author:
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,Hepatology
Link
http://www.nature.com/articles/nrgastro.2011.17.pdf
Reference10 articles.
1. Fuss, I. J. et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12p40 monoclonal antibody. Inflamm. Bowel Dis. 12, 9–15 (2006).
2. Zhang, Z., Zheng, M., Bindas, J., Schwarzenberger, P. & Kolls, J. K. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm. Bowel Dis. 12, 382–388 (2006).
3. Fuss, I. J. et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize and atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113, 1490–1497 (2004).
4. Murphy, K. M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674–680 (2010).
5. Wilson, M. S. et al. Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology 140, 254–264 (2011).
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