TGFβ: the molecular Jekyll and Hyde of cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc1926.pdf
Reference157 articles.
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2. Derynck, R. & Zhang, Y. E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577–584 (2003).
3. Bierie, B. & Moses, H. L. TGF-β and cancer. Cytokine Growth Factor Rev 17, 29–40 (2006).
4. Lin, H. Y., Wang, X. F., Ng-Eaton, E., Weinberg, R. A. & Lodish, H. F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68, 775–785 (1992). Describes the initial cloning and characterization of the type II TGFβ receptor. The binding affinity of TGFβ1 and TGFβ2 was shown, along with an analysis of this receptor as a functional serine and threonine kinase.
5. Wang, X. F. et al. Expression cloning and characterization of the TGF-β type III receptor. Cell 67, 797–805 (1991). Describes the initial cloning and characterization of a type III TGFβ receptor. It was shown that the cloned type III receptor was able to bind TGFβ1 and increase the ligand affinity for the type II TGFβ receptor.
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